The Ghana Mission in Brussels is accredited to the Kingdom of Belgium, The Grand Duchy of Luxembourg and the European Union and is responsible for the co-ordination, promotion and protection of the national interest of Ghana and Ghanaians in the host countries in a manner as to meaningfully contribute to the enhancement of the country's security and socio-economic development. The Mission provides an efficient one-stop reference for general information on Ghana for the effective promotion of trade, investment and tourism.

Ghana is a member of the African Caribbean and Pacific Group of States (ACP Group) which has a partnership with the European Union known as the Cotonou Agreement. The main objective of the ACP-EU Partnership Agreement is to promote sustainable development of Member States and provide a framework for negotiations and agreements. The Mission participates actively in the activities and deliberations of the ACP and has achieved a lot for Ghana and the West African Region  in collaboration with, and through the collective effort of the Group.